Project Gamma

TRAVA, Tandem Repeat Analysis and Visualization Atlas

December 18, 2024

Project Gamma by Adel Sisy named 2025 National STEM Champion

TRAVA addresses the significant challenge of identifying and analyzing tandem repeats, repeated sequences of DNA, in the human genome at a large scale. These tandem repeats are prone to errors during DNA replication, which can lead to genetic mutations and diseases.

One of the critical challenges in genomics is understanding how genetic mutations cause diseases, especially rare genetic disorders that affect 320 million people globally. 95% of these disorders have no FDA-approved treatments, highlighting the need for advanced research tools.

November 21, 2024

Project Gamma's scope was expanded to 192,073 genes and 1,097,790,295 Single Nucleotide Polymorphisms (SNP) with 1,997,416 gene-disease associations across 22 clinical significance types. TRAVA analyzed and visualized 34,728,056 Tandem Repeats in  5,784 specifically selected genes directly connected to 10,988 unique genetic diseases.

October 15, 2024

TRAVA aims to provide genomic researchers with a powerful, large-scale bioinformatics application to analyze and visualize tandem repeats across the human genome. By cataloging about 58 million tandem repeats in 10,068 genes linked to over 82,000 gene-disease associations, TRAVA helps researchers identify mutations that may serve as genetic markers for gene editing technologies like CRISPR, offering potential paths toward treatment or cures.

Project Gamma is currently under development

Second milestone completed on 12/01/2024